Chédiak-Steinbrinck-Higashi syndrome medical definition

An inherited syndrome marked by abnormalities of granulation and nuclear structure of all types of white blood cells; it is often accompanied by hepatosplenomegaly, lymphadenopathy, anemia, thrombocytopenia, radiologic changes of bones, lungs, and heart, skin and psychomotor abnormalities, and susceptibility to infection. Also called Chédiak-Higashi disease, Chédiak-Steinbrinck-Higashi anomaly.